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More about signs of mono

The diagnosis is often obvious from the symptoms and examination of a blood smear, which shows many atypical lymphocytes (white blood cells). There are two general types of blood tests for mono. The first is called a monospot test (or a spot test). Monospot relies on clumping of horse red blood cells by mononucleosis antibodies presumed to be in a person’s serum. The other test is called the heterophil antibodies test. This test looks for antibodies (proteins produced by the immune system to counter the virus) that possess the unique ability to cause clumping of red cells taken from sheep’s blood.
Your physician or healthcare provider will use a variety of laboratory and clinical tests to check signs of mono and symptoms. During your checkup, you will be asked about the things you feel or any discomforts you are experiencing, eventually performing a physical exam.
The diagnosis of mono is confirmed by blood tests.
Mono can cause liver inflammation (hepatitis) and enlargement of the spleen.